Artemethe r

1. Superior in quality and moderate in price. 2. Manufacturers selling,Passed China GMP 3. More than 10 years manufacturing

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The following is artemethe r raw materials show.

 

Artesunat e in chemical,Artemisinin Series

 

Appearance: Odorless bitter-tasting crystalline powder

Extract Solent: Alcohol/water

Artesunat-e: 98%-102%Artesunat-e (INN) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS.SynthesisArtesunat-e is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. Pyridine as base/solvent, sodium bicarbonate in chloroform and catalyst DMAP (N,N-dimethylaminopyridine) and triethylamine in 1,2-dichloroethane have been used, with yields of up to 100%. A large scale process involves treatment of DHA in dichloromethane with a mixture of pyridine, a catalytic amount of DMAP and succinic anhydride. The dichloromethane mixture is stirred for 6–9 h to get artesunat-e in quantitative yield. The product is further re-crystallized from dichloromethane. alpha-Artesunat-e is exclusively formed (m.p 135–137°C).

 

 

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Artemethe r