Artesunate in chemical

1. Superior in quality and moderate in price. 2. Passed China GMP 3. More than 10 years manufacturing skills.

Artesunate in chemical,Artemisinin Series

Appearance: Odorless bitter-tasting crystalline powder

Extract Solent: Alcohol/water

Artesunate: 98%-102%Artesunate (INN) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. It is sometimes abbreviated AS.SynthesisArtesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. Pyridine as base/solvent, sodium bicarbonate in chloroform and catalyst DMAP (N,N-dimethylaminopyridine) and triethylamine in 1,2-dichloroethane have been used, with yields of up to 100%. A large scale process involves treatment of DHA in dichloromethane with a mixture of pyridine, a catalytic amount of DMAP and succinic anhydride. The dichloromethane mixture is stirred for 6–9 h to get artesunate in quantitative yield. The product is further re-crystallized from dichloromethane. alpha-Artesunate is exclusively formed (m.p 135–137°C).

 

Artesunate in chemical